What is Filaggrin?

Filaggrin is a protein that is essential for skin hydration and maintaining the integrity of the skin barrier. It is largely responsible for how well your skin retains moisture, and determines how hydrated and healthy your skin is. Filaggrin is essential for the production of Natural Moisturising Factor (NMF) – substances that maintain skin hydration and skin barrier.

People with eczema-prone skin may be deficient in the gene for making Filaggrin which may result in a shortage of this protein. A lack of Filaggrin makes it easier for moisture to escape as the skin barrier is compromised, making the skin vulnerable and prone to dehydration.


Cetaphil Restoraderm is the first skincare range* with Filaggrin technology™ to help restore your skin’s Natural Moisturising Factor and help rebuild a healthy skin barrier. This in turn helps soothe your skin and reduces itchiness, which aids in stopping the itch-scratch cycle for people with eczema-prone skin. By hydrating and strengthening the skin’s, Cetaphil Restoraderm provides relief from itch and redness for eczema-prone skin.

*Within Cetaphil’s range of skincare products

Always read the label. Follow the directions for use.


Van den Oord RA etal. Filaggrin gene defects and risk of developing allergic sensitisation and allergic disorders: systematic review and meta-analysis. Br J Dermatol. 2009;339:b2433.